Objective: Chronic Rhinosinusitis is a very commonly occurring disease; adversely affecting the health of the population world over. The study aimed to evaluate the efficacy and tolerability of oral Unani formulation with inhalation of Kalonji in Iltehab Tajaweefe Anaf Muzmin (Chronic Rhinosinusitis) and to provide safe, effective, and economical treatment for Chronic Rhinosinusitis. Methods: A randomized single-blind, standard controlled study of forty patients of CRS was undertaken at ENT OPD, Majeedia Hospital and HAH Hospital, Jamia Hamdard, New Delhi. The clinically diagnosed patients were randomly allocated to two groups each consisting of 20 patients. In Group A, Unani oral formulation of Katan (Linum usitatissimum), Filfil siyah (Piper nigrum) & Honey was given 6gm BD with steam inhalation of Kalonji (Nigella sativa) and Tab Alaspan 1BD with Karvol Plus inhalation was given in Group B. Results: Statistical analysis of the data was done using paired T-test by comparing the mean VAS score of all major and minor symptoms before and after treatment. The result is statistically highly significant in Group A (p <0.0001) and it is significant in group B (p<0.01). Conclusion: It may be concluded that the Unani formulation with inhalation of Kalonji has a statistically highly significant effect on major and minor symptoms of Chronic Rhinosinusitis. A multicentric trial of the test drug on a larger sample size for a longer duration is required to establish the efficacy of the formulation on CRS.