The “Practical applications of IIIF: as a building block towards a digital National Collection”, part of the Arts and Humanities Research Council's (AHRC) funded Towards a National Collection Programme, aims to highlight and demonstrate the opportunities and benefits that the International Image Interoperability Framework (IIIF) standard offers to a wide audience of heritage institutions and researchers looking to share, present and re-use high quality images and media on the web. This Zenodo repository presents the documents, videos, and files associated with the Practical Applications of IIIF Presents: A Seminar on Image Registration, held on 11 July 2021, which was facilitated project as an response to the discussion that arose from the project’s first webinar. Image Registration, simply put, is the process of aligning one image on top of another one, yet the process of doing so is remarkably complex. Arising out of the first Practical Applications of IIIF Webinar (https://tanc-ahrc.github.io/IIIFTNC/webinar01.html), and a subsequent call as part of the IIIF Museums Community Group in the beginning of May, it was decided that we needed a dedicated time to discuss not only how Image Registration is currently being employed across various sectors, but also share some recommendations and effective practices, as well as consider the ways in which Image Registration is evolving and how it may be accomplished in the future. To this end, we invited a panel of specialists to share their expertise in what we hope shall be a lively and informative conversation in which participants from the audience are encouraged to actively participate as we discuss the methods, challenges and possibilities of Image Registration Panellists included: Ryan Baumann (Duke University), Giles Bergel (University of Oxford), Andrew Bruce (National Gallery, UK), John Cupitt (Imperial College London), Nathan Daly (National Gallery, UK), Joanne Dyer (British Museum), Rob Erdmann (Rijksmuseum), Adam Gibson (UCL), Luca Carini (V&A), Maria Villafane (Imperial College London), Keats Webb (Smithsonian Institution), Charles Willard (UCL). An introduction to the Session was given by Joe Padfield (National Gallery, UK) Each speaker’s name is hyperlinked to the video of their presentation on YouTube, but as noted, this data set also includes all the documents and files associated with the webinar, namely the pdfs of the slides that accompanied each speaker’s introduction along with any additional resources each speaker wished to provide, the video files, transcripts of the videos, and the chat file that accompanied the webinar. There is also the option to download a zipped file that contains all the videos, transcripts, slide decks, and seminar chat.