Objective. To explore the influence of ambient air pollutant NO2 on the COVID-19 ("Co" stands for coronavirus, "Vi" is for virus and "D" is for disease) in the five various counties of the USA. Methods. Employing openly available data collected by the US Census Bureau, National Aeronautics and Space Administration (NASA), Environmental Protection Agency (EPA), and additional agencies, county-level fatality rates were taken from the literature that was regressed on concentration values of nitrogen dioxide (NO2) (and ground-level ozone), days since very first approved case. Moreover, On March 19, 2018, a matter regarding the nascent COVID-19 pandemic pushed the California government to command lockdown on all Californian residents, except to do certain primary tasks. Results. The study revealed that NO2 has a kind of linear correlation with COVID-19 (county-level mortality rates, including some other parameters) that also produced the O3. Additionally, ground-level ozone is confidently associated with COVID-19 cases (fatality rates). Additionally, s an outcome of lockdown, the usage of individual vehicles drastically lowered. Since these transportations significantly provided to NO2 levels in five mentioned counties of USA, many have queried whether their absenteeism let a drop in NO2 pollution. Conclusions. High NO2 concentrations and ground-level O3 object to a higher COVID-19 case and fatality rate. To check additional deaths, it is essential to follow lockdown limitations and also speculate research verdicts in public systems. In the fact of air pollution or contamination, environmental constraints should be augmented, and additional anticipations should be practiced as plants start resuming.