The purpose of this report is to present the final design of the HUTER Platform architecture, an evolution of the previous version reported in deliverable D2.1 of month 9 (document entitled “HUTER_WP2_D2.1_Platform_architecture_design”). The HUTER platform aims to support the research activities related to uterus cell map as well as other ambitious objectives such as develop a platform applicable not only in the context of uterus research (e.g. severe preeclampsia) but also adaptable and usable for other cases or diseases. As research activities have been developed, new requirements and specifications for the HUTER platform have been arisen which are collected in this report. Thus, the present document contains upgrades and improvements with the aim of being fully aligned with the last advancements of the project. The main changes have been mostly based on partner’s progress in data collection, metadata and pipelines definitions as well as the feedback provided by HCA in our meetings with the aim of guaranteeing data and metadata transferring between both platforms (HUTER and HCA-DCP). Furthermore, some technical features briefly defined in deliverable D2.1 document are even further detailed and explained in this report. However, we want to highlight that the major content of the previous version, deliverable D2.1, remains in this report in order to offer the reader a better understanding of the whole HUTER architecture design. The final platform architecture design reported herein is one of the key deliverables of WP7 “Platform integration” defined in the Grant Agreement. This document has been developed by BAHIA as lead of WP7 Platform integration, in close collaboration with the rest of the HUTER partners involved in this work package (INCLIVA, GRL, UPPSALA, CCHT and UEA).