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Asteroseismology is well-established in astronomy as the gold standard for determining precise and accurate fundamental stellar properties like masses, radii, and ages. Several tools have been developed for asteroseismic analyses, but nearly all of them are closed-source and therefore not accessible to the general astronomy community. Here we present pySYD, a Python package for detecting solar-like oscillations and measuring global asteroseismic parameters. pySYD was adapted from the IDL-based SYD pipeline, which was extensively used to measure asteroseismic parameters for Kepler stars. pySYD was developed using the same well-tested methodology, but has improved functionality including automated background model selection and parallel processing as well as improved flexibility through a user-friendly interface. Well-documented, open-source asteroseismology software that has been benchmarked against closed-source tools are critical to ensure the reproducibility of legacy results from the Kepler mission.