Major facilitator superfamily domain-containing protein 10 (MFSD10) A Target Enabling Package (TEP)

Authors: Pascoa, Tomas C.; Pike, Ashley C.W.; Bushell, Simon R.; Quigley, Andrew; Shubhashish M.M. Mukhopadhyay; Burgess-Brown, Nicola A.; Carpenter, Elisabeth P.;

doi: 10.5281/zenodo.5126807 , 10.5281/zenodo.5126784 , 10.5281/zenodo.5126783

Major facilitator superfamily domain-containing protein 10 (MFSD10) A Target Enabling Package (TEP)

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Abstract

MFSD10 (also known as TETRAN in humans) has been proposed to function as an organic anion efflux pump and as a transporter for some NSAIDs. We have produced milligram quantities of purified recombinant protein and solved its structure in an outward-facing state at 2.6 Å resolution by X-ray crystallography. The structure - the first example for a human atypical SLC - provides the initial clues to understanding the broad specificity of its putative substrate-binding site.

This document represents version 1 of the TEP datasheet and includes all updates on the project as of June 2021. For more information about TEPs and the TEP Programme, please visit https://www.cmd.ox.ac.uk/resources/teps

Keywords

disease, structure discovery, NSAIDs, SLC, chemical probe, TETRAN, inflammatory diseases, chemical biology, structural genomics, drug target, drug discovery, inflammation, target enabling package, cancer, neuropsychiatry, genetics, Integral Membrane Proteins, structure, orphan disease, inflammatory disorders, protein

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