Abstract The lack of periodontal ligament (PDL) support in the implant bone junction is a matter of concern for implant treatment. The direct contact between bone to implant transmit forces directly to bone and reduces its functional efficiency. Several modifications in implant design and implant surface have been tried and tested. Recently bio-engineering and regenerative dentistry has thrown new lights in the modification of dental implant and to eliminate these drawbacks. Stem cell incorporated bio engineered implant also known as bio- hybrid implant has the potential to generate PDL and nerve cells along the implant bone junction. Pluripotent cells present on the bio-hybrid implant surface also have the ability of bone remodeling, wound healing and neuro transmission. This review article highlights recent status in the development of bio-hybrid implants along with its function and advantages