In the past couple of years in Nigeria, records show that over three thousand (3,000) vehicles are involved in road traffic accidents annually. This is extremely high considering the loss of property and lives involved. The bid to minimize this appalling statistical record is the impetus for this work whose aim is to design and construct a vehicle anti-collision system that can be installed in vehicles to minimize car accidents. The vehicle anti-collision system is vital in improving vehicle safety design and reducing driver errors. It makes use of ultrasonic sensors connected to ATMEGA328P Microcontroller, programmed to give real-time audio-visual signals to the driver after sensing danger via an alarm and display panel installed on the dashboard of the vehicle. The system was designed, constructed and satisfactorily tested. It was able to provide audio-visual signals for possible obstacles from a distance of 200 cm to infinity. Hence, the system can successfully alert and arouse a driver thereby preventing collisions and minimizing accidents.