These are the processed BCR repertoire bulk sequencing data described in Schmitz, Turner & Liu et al., Immunity, 2021. The raw sequence data are available on SRA under BioProjects PRJNA731610 and PRJNA741267. Summary: Bulk-sorted total plasmablasts and IgDlo enriched B cells from PBMCs and germinal centre B cells from lymph nodes from various timepoints after primary immunization from 22 BNT162b2 vaccinees who had no prior history of infection with SARS-CoV-2. Metadata file: WU368_schmitz_et_al_immunity_2021_meta.tsv Abbreviations: LN = lymph node PB = plasmablast GC = germinal center mAb = monoclonal antibody BCR data file: WU368_schmitz_et_al_immunity_2021_bcr.tsv.gz In addition to the processed bulk sequences, also included are the heavy chains of 37 mAbs (including 2C08) first reported in Turner & O'Halloran et al., Nature, 2021 that had been validated to be spike-binding. The mAbs are annotated as "mab" in the "seq_type" column. Sequence data column description The columns largely follow the AIRR-C Rearrangement format. The main deviation is that CDR3s are used, as opposed to IMGT-defined "junctions". Non-standard columns are noted below. v_call_genotyped: V gene annotation reassigned after individualized genotyping by TIgGER isotype: IGH[ADEGM] cdr3: CDR3 nucleotide sequence cdr3_length: CDR3 nucleotide sequence length cdr3_aa: CDR3 amino acid sequence donor: vaccinee ID sample: sample ID (arbitrary) timepoint: time point at which sample was collected tissue: tissue from which sample was collected sorting: FACS sorting seq_type: sequence type (mAb or bulk)