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Running Head: Gliablastome Multiforme The Effectivenes Of Hyperbaric Oxygen Therapy And Sorofenib In An Established Intracerebral Tumor Model In Rats Using The C6 Glial Cell

descriptionPublicationkeyboard_double_arrow_right Article 15 Apr 2016Publisher:ZenodoJournal:The Journal of medical research, volume 3 (issn: 0097-3599,

Authors: Akin Savas Toklu; Tolga Dundar; Sevket Evran; Raziye Atar Physiotherapist; Serkan Kitiş; Mehmet Hakan Seyithanoglu; Ayhan Bilir; +1 Authors

doi: 10.5281/zenodo.50334

Running Head: Gliablastome Multiforme The Effectivenes Of Hyperbaric Oxygen Therapy And Sorofenib In An Established Intracerebral Tumor Model In Rats Using The C6 Glial Cell

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Abstract

Gliomas are the most common brain tumour in adults. Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy. Tumor-related endothelial cells are of neoplastic nature and have malignant properties such as proliferation and invasion. Therefore, antiangiogenic approaches have several advantages compared with conventional chemotherapeutic approaches. This study was undertaken to investigate the preventive or therapeutic effect of hyperbaric oxygen therapy (HBOT) in an established intracerebral tumor model. In this regard, parameters such as the tumor size, vascularization rate, midkine (MK), nuclear factor kappa B (NF-kB), HIF-1 alpha, and caspase 3 were compared in the relevant groups.

Related Organizations

Zirve University
Turkey
Bezmiâlem Vakıf Üniversitesi
Turkey

Keywords

Gliaomas, C6 Glial cell, Hypernaric, GBM etc

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