Cannabis is one type of narcotics that is prohibited from use in Indonesia. The prohibition of Cannabis can be found listed in the Attachment to Law Number 35 of 2009 concerning Narcotics as amended. Cannabis is included in Category I of narcotics that cannot be used for research and medical purposes. However, history proved Cannabis can be used as a medical ingredient for treatment in many cases, even though Cannabis is prohibited in Indonesia. This research discusses the legal politics of medical Cannabis in Indonesia in view of the possibility to legalize the use of medical Cannabis. This study is normative legal research using secondary data. The historical and comparative approach is used to support the research. The research showed that historically, Indonesia and Thailand were among many countries that were suffered from the prohibition to use Cannabis for medicine. Indonesian legal politics proved that it is actually open for interpretation dan discussion over the use of Cannabis medical. The study recommends that cannabis medical research must be further encouraged.