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The evaluation of the morphological and biochemical blood parameters is extremely helpful after orthopedic procedures as it could be used as an indicator for the quality of the regeneration process. There were significant changes in the RBC count, amount of Hb and Hct in the postoperative period. We observed an increase in the total number of platelets as a result of the soft tissue and bone trauma, destruction of blood vessels, etc. All the changes in the post-surgical period regarding the biochemical parameters reflect the changes that occur in the macro-organism after anesthesia and surgery. Serum alkaline phosphatase differences in all groups is because of different activation of osteoblasts, producing specific bone alkaline phosphatase.