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A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis

descriptionPublicationkeyboard_double_arrow_right Article 18 Feb 2020 Sweden English Publisher:American Chemical Society (ACS)Journal:Journal of Natural Products, volume 83, pages 316-322 (issn: 0163-3864, eissn: 1520-6025, Copyright policy )Funded by:ARC | Screening platforms for m..., VR | unidentified
Authors: Maeda, Gasper; Munissi, Joan J. J.; Lindblad, Sofia; Duffy, Sandra; Jerry Pelletier; Avery, Vicky M.; Nyandoro, Stephen S.; +1 Authors

doi: 10.1021/acs.jnatprod.9b00721 , 10.5281/zenodo.3355164 , 10.5281/zenodo.4906326 , 10.5281/zenodo.3355165

pmid: 32067457

pmc: PMC7343278

handle: 10072/395813

A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis

Abstract

NMR data including FIDs, mnova files and NMReDATA. A new meroisoprenoid (1), two heptenolides (2, 3), two C-benzylated flavonoids (4, 5) and eleven known compounds (6-16) were isolated from the leaf, stem bark and root bark extracts of Sphaerocoryne gracilis ssp. gracilis by chromatographic separation. The structures of the isolated metabolites were identified by NMR, IR and UV spectroscopic and mass spectrometric data analyses. (Z)-Sphaerodiol (7), (Z)-acetylmelodorinol (8), 7-hydroxy-6-hydromelodienone (10) and dichamanetin (15) inhibited the proliferation of Plasmodium falciparum (3D7, Dd2) with IC50 values of 1.4-10.5 μM; however, they showed cytotoxicity against human embryonic kidney cells (HEK-293). None of the compounds exhibited significant disruption in protein translation when assayed in vitro.

Original NMR FIDs for the published compounds

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Sweden
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Keywords

Aromatic compounds, Biomedical and clinical sciences, Meroisoprenoid, Heptenolide, C-Benzylated Flavonoid, Sphaerocoryne gracilis, NMR, natural product, malaria, cancer, Plasmodium berghei, Plasmodium falciparum, Annonaceae, Medicinal, Antimalarials, Humans, Pharmacology & Pharmacy, Light absorption, Nuclear magnetic resonance spectroscopy, Flavonoids, Organisk kemi, Science & Technology, Molecular Structure, Plant Extracts, Plant Sciences, Organic Chemistry, complementary and integrative medicine, Traditional, Carbon, Plant Leaves, Biological sciences, Chemistry, Metabolism, HEK293 Cells, Chemical sciences, Flavanones, Life Sciences & Biomedicine

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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