Introduction: People with high systolic blood pressure but no known cardiovascular disease is at risk for developing mitral regurgitation (MR), a longitudinal study suggests. Objectives: The main objective of the study is to find the relation of elevated blood pressure and risk of mitral regurgitation. Material and methods: This correlational study was conducted in Nishtar Medical College, Multan during 2020. The data was collected from both genders and age range was 30 to 60 years. We exclude all the patients who were at baseline and had a previous history of CVD. Our primary outcome was incident reports of mitral regurgitation, which were identified from hospital discharge reports, death registers, or primary care records. Results: The data was collected from 50 patients of both genders. The mean age of the patients was 55.67 ± 5.87 years. The baseline values are presented in Table 1. Conclusion: It is concluded that long-term exposure to elevated BP across its whole spectrum is associated with an increased risk of primary and secondary mitral regurgitation.