The file: Dataset 1.xlsx, contains information related to deaths and the respective dictionary of variables. The file: Dataset 2.xlsx, contains information related to those injured by motorcyclist road incidents "in situ" obtained from police records and the respective dictionary of variables. The file: Dataset 3.xlsx, contains information related to the records of injuries treated for motorcyclist road incidents treated in the health services and the respective dictionary of the variables The file: S1_Table.docx, contains the information about nature of lesions and assigned ICD10 codes. The file: S2_Table.docx, contains the information about disability weights by nature of injury according to GBD The file: S3_Table.docx, contains the information about number of deaths “in situ” injuries, injuries attended, YLL, YLD and DALY for motorcyclist road incidents per year, according to sex and age groups, Medellín, 2012-2015. The file: S4_Table.docx, contains the information about Distribution of YLD due to motorcyclist road incidents according to the nature of injury and the number of injuries per event.