Two simple, sensitive, accurate, precise, rapid and economical methods were developed for the estimation of Ofloxacin and Tinidazole from combined tablet dosage form. First method is based simultaneous equation and second method is based on ‐analysis (absorbance ratio method). Ofloxacin and Tinidazole show at 300 nm and 275 nm in 0. Methanolic‐HCI (20:80) respectively. The linearity was obtained in the concentration ranges of for Ofloxacin and for Tinidazole with Regression Coefficient (R2) greater than 0.999. In the first method concentration and subsequently amount of drug determined by using simultaneous equations and in second method concentration and amount of drug determined by using ratio of absorbance at Iso‐absorptive point (which was found to be 286 nm) and at of one of the drugs. The results of analysis have been validated statistically and subsequently by assay and recovery studies.