The main objective of NANORIGO (NANOtechnology RIsk GOvernance) is to develop and implement a transparent, transdisciplinary and science-based Risk Governance Framework (RGF) for managing possible nanotechnology risks regarding social, environmental and economic benefits. A new risk management approach is formed based on available high-quality data and advanced scientific tools developed for industry and regulators’ decision-making, and on communication with all stakeholders (regulators, industries, politicians, the civil society). The RGF will use a life-cycle perspective and integrate available knowledge on ethical, social, environmental, and economic concerns into a user-friendly format that can be easily adapted and transferred into regulation for hazard, exposure and risk assessment and management of nanomaterials. It will consist of: (i) risk management strategies based on reinforced tools for guidance and decision-making developed for risk assessment, (ii) validated methodologies to identify potential hazard and exposure, and (iii) a web-based information and communication platform to facilitate access to good quality data and a clear risk understanding of stakeholders, and their valuable feedback. The NANORIGO work plan consists of 7 work packages covering all major risk governance aspects. Finally, a self-sustained European Risk Governance Council (ERGC) will be established and implemented by NANORIGO and all relevant stakeholders, and embedded in relevant international structures, in close cooperation with the International Risk Governance Center (IRGC). Case studies will demonstrate the sustainability of solutions and their consistent integration into regulatory applications under real conditions. For the first time, all stakeholders will be brought together under a common “umbrella” to share and integrate the most appropriate governance tools, frameworks and plans for future scientific and regulatory research and to foster consistency of management approaches in the EU and synergies internationally.