Extracellular vesicles transport variable content and have crucial functions in cell-cell communication. The role of extracellular vesicles in cancer is a current hot topic, and no bibliometric study has ever analyzed the research production regarding their role in breast cancer and indicated the trends in the field. Thus, articles were searched and retrieved from Scopus, including all the documents ever published concerning Breast cancer and Extracellular Vesicles. We analyzed authors, journals, citations, affiliations, keywords, besides other bibliometric analyses, using R Studio version 3.6.2., and VOSviewer version 1.6.0. In the total, 1151 articles were retrieved, of them, 72.28% were published in the last 4 years. Our analysis revealed trends topics on liquid biopsy, drug delivery, chemotherapy, autophagy, and microRNA. Additionally, research related to extracellular vesicles in breast cancer has been focused on diagnosis, treatment, and mechanisms of action of breast tumor-derived vesicles. Future studies are expected to explore the role of extracellular vesicles on autophagy and microRNA, besides investigating the application of extracellular vesicles from liquid biopsies for biomarkers and drug delivery, enabling the development and validation of therapeutic strategies for specific cancer. These trends are highly promising and constitute significant research strategies shortly.