Medical images provide diagnostic evidence/information about anatomical pathology. The growth in database is enormous as medical digital image equipment’s like Magnetic Resonance Images (MRI), Computed Tomography (CT), and Positron Emission Tomography CT (PET-CT) are part of clinical work. CT images distinguish various tissues according to gray levels to help medical diagnosis. Ct is more reliable for early tumours and haemorrhages detection as it provides anatomical information to plan radio therapy. Medical information systems goals are to deliver information to right persons at the right time and place to improve care process quality and efficiency. This paper proposes an Artificial Immune System (AIS) classifier and proposed feature selection based on hybrid Bacterial Foraging Optimization (BFO) with Local Search (LS) for medical image classification.