Analysis of mutational antigenic profiling of barcoded codon variants of SARS-CoV-2 RBD. The code repository itself can be found here. Interactive visualizations of the data can be found here. Study and analysis by Allie Greaney, Tyler Starr, Jesse Bloom, and co-authors. These experiments are described in this preprint. This work examines mutations that reduce binding by polyclonal serum antibodies from individuals vaccinated with the Moderna mRNA-1273 vaccine, and compares the results to those from individuals infected with SARS-CoV-2. The vaccine samples are from the mRNA-1273 phase 1 study, funded by the National Institutes of Allergy and Infectious Diseases. This version was archived with the resubmission of the manuscript to Science Translational Medicine.