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Data to reproduce findings in the manuscript "Single-cell transcriptomics identifies synergistic role of leukemic and non-leukemic immune repertoires in CD8+ T-cell Large Granular Lymphocytic Leukemia". The folder contains: 1) Processed scRNA+TCRab-seq data in a Seurat-folder, including * Object with 11 T-LGLL samples and 6 healthy samples * Object with only hyperexpanded (>= 10 TCRs) T-cells from all T-LGLL samples and 6 healthy samples * Object with only T-LGLL clones from 11 T-LGLL samples * Object with non-leukemic repertoires from 11 T-LGLL samples, 6 healthy samples, 4 CML samples, 4 CLL samples, 2 RCC samples, and 1 NSCLC sample 2) TCRb-seq samples from CD8+ sorted peripheral blood samples from patients with CD8+ T-LGLL Please see manuscript and Github for further details.
T-LGLL, LGL, scRNAseq, single-cell, TCR
T-LGLL, LGL, scRNAseq, single-cell, TCR
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