This work was supported by the Spanish Agencia Estatal de Investigación (AEI) and the ERDF (PID2019-111126RB-100, RTI2018-098795-A-I00, and PID2019-111327GB-I00) and by the Xunta de Galicia and the ERDF (ED431F 2020/05, ED431C 2017/25, and Centro singular de investigación de Galicia accreditation 2016-2019, ED431G/09). M.C. thanks Xunta de Galicia for a predoctoral fellowship (ED481A-2017/ 068). R.G.-F. thanks Ministerio de Ciencia, Innovación y Universidades for a "Ramón y Cajal" contract (RYC-2016-20335). P. F. G. thanks the Spanish Ministry of Economy and Competitiveness and the EuropeanSocial Fund for his predoctoral research grant, reference BES-2016-076761. All calculations were carried out at the Centro de Supercomputación de Galicia

In this work, we study peptide nanotubes comprised of α-amino acids and cyclic δ‐amino acids. Their stability when inserted in a lipid bilayer, as well as their utility as transmembrane channels is assesed, in order to elucidate their potential application as synthetic transmembrane channels; via Molecular Dynamics simulations.