Background: Nocturnal enuresis is the inability to control urination. It represents a common health problem among young children and adolescents. Nocturnal enuresis is the second most common condition affecting children aged 6 to 14 years after allergic disorders. Methodology: this was a cross-sectional study conducted among young Saudi children to determine the prevalence of nocturnal enuresis and associated risk factors. An online adapted questionnaire was distributed among the children's parents to fulfill the study objects. Results: Among the 432 included children, 53.2% were females and (31.5%) aged 5-7 years. There was a significant association between the child's age (P=0.000), gender (P=0.040), and father's education (P=0.096) and nocturnal enuresis. The parents' and siblings' family history, hospital admission, blood grouping, suffering from diabetes, and UTI also has a significant association with the prevalence of nocturnal enuresis (P=0.032), (P=0.000), (P=0.024), (P=0.004), (P=0.000), and (P=0.006), respectively. Conclusion: We demonstrated a high prevalence of nocturnal enuresis among young Saudi children. Family history was significantly associated with the enuresis prevalence. High prevalence of diurnal enuresis and which caused social shame to most of the participants. Children who were admitted to hospital after delivery, born with obstructed, and those suffered from diabetes and UTI were found to have the highest prevalence of enuresis. Keywords: Nocturnal enuresis; Pediatric; Saudi Arabia