The present work concerned with the formulation and evaluation of Orodispersible tablet of Granisetron Hydrochloride by using Natural Superdisintegrants Banana powder. Granisetron HCL is a novel serotonin 5-HT3 receptor used as antiemetic to treat nausea and vomiting during cancer chemotherapy but its oral bioavailability is low due to extensive first pass metabolism in liver which makes it ideal candidates for orodispersible tablet. Banana Powder itself has Antiemetic properties which prevents the Nausea and Vomiting. Pre compression studies revealed good micrometric properties of powder blend. Various formulation of were prepared by direct compression method and were evaluated for their physio chemical properties, drug release and stability studies. FTIR and DSC show that there is no interaction with drug and other excipients. From this study, we can conclude that, a formulated tablet of Granisetron HCL containing Banana Powder is better and effective to meet the patient compliance. Reserchers have found that Banana powder treatment not only strengthens mucosal resistance against ulcerogens but it’s also promotes healing by inducing cellular proliferation. Banana powder mainly used as natural superdisintegrants when compared to synthetic superdisintegrants. The hardness, friability, drug content and disintegration time of Orodispersible tablets were found uniform and reproducible. The main aim of the study was to develop orodispersible tablets of Granisetron hydrochloride a selective 5-HT3 receptor antagonist (antiemetic agent) for improving patient compliance, especially those of paediatric and geriatric categories with difficulties in swallowing. From this study it is concluded that orodispersible tablets could be prepared by direct compression method using Natural superdisintegrants enhanced dissolution will lead to improved bioavailability, improved effectiveness of Granisetron. The present study comprises the various kinds of natural superdisintegrants which are being used in the formulation to provide the safest, effective drug delivery with patient’s compliance. By using Banana powder, it shows good result in given formulation batch. Key words: Orodispersible tablet, Granisetron HCL, Banana powder, Superdisintegrants, Antiemetic The present work concerned with the formulation and evaluation of Orodispersible tablet of Granisetron Hydrochloride by using Natural Superdisintegrants Banana powder. Granisetron HCL is a novel serotonin 5-HT3 receptor used as antiemetic to treat nausea and vomiting during cancer chemotherapy but its oral bioavailability is low due to extensive first pass metabolism in liver which makes it ideal candidates for orodispersible tablet. Banana Powder itself has Antiemetic properties which prevents the Nausea and Vomiting. Pre compression studies revealed good micrometric properties of powder blend. Various formulation of were prepared by direct compression method and were evaluated for their physio chemical properties, drug release and stability studies. FTIR and DSC show that there is no interaction with drug and other excipients. From this study, we can conclude that, a formulated tablet of Granisetron HCL containing Banana Powder is better and effective to meet the patient compliance. Reserchers have found that Banana powder treatment not only strengthens mucosal resistance against ulcerogens but it’s also promotes healing by inducing cellular proliferation. Banana powder mainly used as natural superdisintegrants when compared to synthetic superdisintegrants. The hardness, friability, drug content and disintegration time of Orodispersible tablets were found uniform and reproducible. The main aim of the study was to develop orodispersible tablets of Granisetron hydrochloride a selective 5-HT3 receptor antagonist (antiemetic agent) for improving patient compliance, especially those of paediatric and geriatric categories with difficulties in swallowing. From this study it is concluded that orodispersible tablets could be prepared by direct compression method using Natural superdisintegrants enhanced dissolution will lead to improved bioavailability, improved effectiveness of Granisetron. The present study comprises the various kinds of natural superdisintegrants which are being used in the formulation to provide the safest, effective drug delivery with patient’s compliance. By using Banana powder, it shows good result in given formulation batch. Key words: Orodispersible tablet, Granisetron HCL, Banana powder, Superdisintegrants, Antiemetic