as determination of microbiological characteristics, alpha-2-microglobulin in blood serum Materials and methods. Microbiological research and diagnosis of deoxyribonucleic acid of possible pathogens of CE, determination of embiotropic autoantibodies in blood serum (ELI-P-test), determination of the content of alpha-2-microglobulin (AMGF) in menstrual blood, sonographic, hysteroscopic and pathomorphological studies (aspirates and biopsies from the cervical canal and uterus). Results. The results of the data showed that pathological changes in the body's immunoreactivity with each macrotype of chronic endometritis, as well as the determination of microbiological features, alpha-2-microglobulin in the blood serum are prognostic indicators of structural and functional changes in the endometrium in various types of chronic endometritis Keywords: chronic endometritis, alpha-2-microglobulin, immunoreactivity, diagnostics.