Studies have shown that the use of the synthetic hormone melatonin is safe. A significant harm/benefit ratio in favor of the benefit is revealed. The use of the drug is recommended for manifestations of insomnia, such as difficulty falling asleep or periodic night awakenings, as well as to prevent Jetlag syndrome when changing time zones. Melatonin is able to correct endocrine imbalances leading to metabolic disorders. There is evidence that, in combination with calcium, melatonin is able to reduce the proportion of body fat and prevent obesity by stimulating anabolic processes in favor of the formation of "beige fat".