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A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

descriptionPublicationkeyboard_double_arrow_right Article 24 Nov 2020Publisher:Zenodo
Authors: Cheng; Porritt; Noval Rivas; Krieger; Ozdemir; Garcia Jr; Arumugaswami; +3 Authors

doi: 10.5281/zenodo.4667693 , 10.5281/zenodo.4667694

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

Abstract

Representative coordinate files in PDB format (homology models and docking models) from the work which first appeared on bioRxiv and later accepted for publication by Structure. A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro Mary Hongying Cheng, Rebecca A. Porritt, Magali Noval Rivas, James M Krieger, Asli Beyza Ozdemir, Gustavo Garcia Jr, Vaithilingaraja Arumugaswami, Bettina C. Fries, Moshe Arditi and Ivet Bahar bioRxiv 2020 Nov 24;2020.11.24.395079. doi: 10.1101/2020.11.24.395079. Preprint https://pubmed.ncbi.nlm.nih.gov/33269352/ Six PDB files are uploaded (1) Homology model of human TMPRSS2. (2) Docking model of SARS-CoV-2 Spike bound to TMPRSS2. (3) Docking model of SARS-CoV-2 Spike bound to furin. (4) Docking model of antibody 6D3 bound to SARS-CoV-2 spike in one up state. (5) Docking model of antibody 6D3 bound to SARS-CoV-2 Spike in down states. (6) Docking model of antibody 6D3 bound to HCoV-OC43 Spike in down states.

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