Anti-TB drugs have shown that they are able to contain and kill Mycobacterium tuberculosis effectively; they are known to induce various adverse effects, including liver injury, skin reactions, gastrointestinal and neurological disorders. Anti-tuberculosis drug induced liver injury (ATLI) is one of the most important and serious adverse effects, which results in a low treatment success rate. Hepatitis adverse effect seen in tubercular suffered patient due to anti tubercular drug therapy. Case: In this case, the patient was receiving anti-tubercular drugs from 3 months and developed hepatitis which is a severe adverse drug reaction. Naranjo's causality assessment algorithm was used to assess the adverse effect and it indicated anti-tubercular drugs as probable cause of hepatitis. Key Words: Hepatitis, Anti-tubercular drugs, ADR Analysis, Re-Challenge and De-Challenge.