All data supporting the findings of the publication "NaroNet: Objective-based learning of the tumor microenvironment from highly multiplexed immunostained images", including multiplex images, ground-truth masks, and patient data. The code used to produce the results of this study is available at https://github.com/djimenezsanchez/NaroNet Synthetic_experiments.zip. contains synthetic patient cohorts generated from the synthetic tissue simulator called Synplex. Synplex tissue generator is thoroughly described in the arxiv preprint https://arxiv.org/abs/2103.04617 Endometrial_High_grade_cancer.zip contains tiff stacks and patient data for the endometrial high-grade cancer cohort. Note that the endometrial high-grade cancer images provided are already unmixed.