Background: Chronic obstructive pulmonary disease (COPD) is the 4th principal reason of mortality globally. It is an escapable and curable ailment, for which physicians have to inaugurate an impulsive and precise verdict and management, comprising teaching for prophylaxis. COPD is a chief source of morbidity and mortality worldwide. This study was conducted to define role of CRP as indicator of antibiotic therapy among patients with COPD. Study Design: Descriptive case series Study Place and Duration of Study: This study was conducted at the Department of Pulmonology, Benazir Bhutto Hospital Rawalpindi, for the duration of six months, from January, 2020 to June, 2020. Materials and Methods: The study included 100 cases fulfilling inclusion criteria. Serum CRP levels were measured in all patients and were categorized as: low CRP (<40 mg/L) and high CRP (>40 mg/L). Patients in both groups received antibiotic therapy (Levofloxacin 500mg twice daily per oral) for 7 days. Patients were assessed for clinical success (absence of dyspnea and sputum). Results: High CRP level was observed in 65(65%) patients and low in 35(35%) patients. Clinical success was achieved among 14(40%) patients in low CRP group and 56(86.2%) patients with high CRP group (p<0.05). Conclusion: Majority of patients had high CRP level (>40mg/L). So, CRP level can be used as an indicator for commencement of antibiotic therapy among patients with acute exacerbation of COPD. Key Words: Chronic obstructive pulmonary disease; C–reactive Proteins; antibiotic therapy