In this issue, our Coordination Team update highlights, among other activities, the NanoHarmony webinar being held on 17th March, and the recent innovative developments of the Safe-By-Design initiatives. Meanwhile, for those who would like to follow up on the NSC Education and Training days at nanoSAFE, the videos are now available on our Youtube Channel (p3) as a playlist. The New Projects section introduces four new initiatives that are working from the Safe & Sustainable by Design and Safety Innovation Approach perspectives. Following this, Project News brings you the latest updates from a number of current initiatives (see contents). From p.24, you can discover more about five micro-/nano-plastics projects that kick off next month with the aim of finding out more about the health impacts of mnps on the human body. These projects will be forming an mnp cluster: more will be announced in the next NSC Newsletter. In the Publications section, PATROLS and NANORIGO have a number of papers now available. Links to new research in neurotoxicology and particle and fibre toxicology are also highlighted. BIORIMA then offers a virtual library of research that’s highlighted every week on twitter. The busy Events section announces key forthcoming conferences which, inevitably, will be held online for the first half of this year at least. NanoTox 2021 is open for registration. Meanwhile, at ENF21, a number of NSC projects will be showcasing their outputs and activities. Registration now for free. It’s also worth noting that the European Research and Innovation Days will be held earlier this year from 23rd - 24 June 2021.