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Multi-omics data harmonisation for the discovery of COVID-19 drug targets

Authors: Chen, Tyrone; Philip, Melcy; Abadi, Al J; Lê Cao, Kim-Anh; Tyagi, Sonika;

Multi-omics data harmonisation for the discovery of COVID-19 drug targets

Abstract

We present a generic, flexible, reproducible, open-access data harmonisation framework that can be scaled out to future multi-omics analysis to study a phenotype in a holistic manner. Our git repository along with code, documentation and sample data on two case studies are available with install instructions. The pipeline can also be installed as an R package: install.packages(devtools) install_gitlab("tyagilab/sars-cov-2", subdir="multiomics", build_vignettes=TRUE) Please view our publication for more information: @article{10.1093/bib/bbab185, author = {Chen, Tyrone and Philip, Melcy and Lê Cao, Kim-Anh and Tyagi, Sonika}, title = "{A multi-modal data harmonisation approach for discovery of COVID-19 drug targets}", journal = {Briefings in Bioinformatics}, year = {2021}, month = {05}, issn = {1477-4054}, doi = {10.1093/bib/bbab185}, url = {https://doi.org/10.1093/bib/bbab185}, note = {bbab185}, eprint = {https://academic.oup.com/bib/advance-article-pdf/doi/10.1093/bib/bbab185/38130519/bbab185.pdf}, }

{"references": ["https://doi.org/10.1093/bib/bbab185"]}

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Keywords

sars-cov-2, machine learning, covid-19, coronavirus, multi-omics, multi omics, multiomics

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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