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ZENODO
Article . 2021
License: CC BY
Data sources: Datacite
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ZENODO
Article . 2021
License: CC BY
Data sources: ZENODO
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ZENODO
Article . 2021
License: CC BY
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STABILITY INDICATING RP-UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF GLECAPREVIR AND PIBRENTASVIR IN BULK AND TABLET DOSAGE FORMS

descriptionPublicationkeyboard_double_arrow_right Article 24 Feb 2021Publisher:Zenodo
Authors: Naga Venkata Indira Devi Jajula*, Prof. Gowri Sankar D;

doi: 10.5281/zenodo.4558686 , 10.5281/zenodo.4558685

STABILITY INDICATING RP-UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF GLECAPREVIR AND PIBRENTASVIR IN BULK AND TABLET DOSAGE FORMS

Abstract

A novel, simple, accurate and rapid method has been developed and validated for and in bulk and in tablet dosage form. In RP-UPLC method, elution was achieved in isocratic mode using combination of Glecaprevir and Pibrentasvir in the ratio of 0.1% OPA: Acetonitrile (60:40) using a HH C18 (100×2.1mm, 1.8µm) column. The flow rate was 1ml/min and detection was done at 260nm.The method was validated for linearity, accuracy, precision, specificity and sensitivity as per ICH norms. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form. Keywords: Glecaprevir, Pibrentasvir, RP-UPLC, Validation.

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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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