Plan: Formulation and evaluation and of Silver Sulfadiazine Laden Topical Formulation for treatment of Burn Wound. Preface: Burn injuries are very complex. One of the golden treatments in topical burn is silver sulfadiazine (SSD).The hydrogels are non- solid dosage forms that produce a flexible, occlusive film in-situ after application on the skin or any other body surface. Methodology: The hydrogel matrix was prepared with combinations of PVA & PVP, HPMC E5LV, and HPMC E15LV. The prepared hydrogel were evaluated for their various physicochemical properties. The optimized formulation F3 was selected by antimicrobial activity by agar diffusion technique. Outcome: All the formulations showed better antimicrobial activity when compared with marketed SSD cream. The formulation F3 was found to be the optimized formulation.