Background: Mechanical neck pain is soreness that rises from the posterior element of the cranium and travels toward the decrease cervical spine and shoulders. In this discomfort, vertebral arrangements are disturbed and the joints of the cervical spine and ribs fail to perform the correct biomechanical movements resulting in reduced mobility, which creates pain. In this study, Mulligan sustained natural apophyseal glides (SNAGS) and natural apophyseal glides (NAGS) will be applied in mechanical neck pain subjects to reduce the immobility and relieve pain. Aims & Objectives: The main objective of the research is to compare the effectiveness of Mulligan SNAGs and NAGs in reducing immobility and relieving pain in patients suffering from mechanical neck pain. Methodology: A randomized clinical trial with simple random sampling by random number table was conducted. A sample size of 50 (n=50) subjects was taken from physiotherapy department of Madinah Teaching Hospital, who fulfilled the selection criteria and was distributed into two equal groups of (A-B) twenty-five (25) each. The researcher signed a prior informed consent from all participants before any inspection or examination. The base line treatment is same for both groups, which is the range of motion, strengthening exercises and group A will receive Mulligan SNAGS while group B will receive Mulligan NAGS. Treatment frequency was three times per week for two weeks. Subjects were assessed at the start of the management and at the completion of second week. Whole data was collected using Wong-Baker faces pain scale (WBFPS) and Neck disability index (NDI) to asses change in pain intensity and data was analyzed by SPSS version 20. Results: Pain intensity after treatment with SNAGs (df = 48, p<0.05). Pain intensity with NAGs has (df = 48, p<0.05). Pain intensity after treatment with SNAGs was lower (Mean=3.16) than after NAGs treatment (Mean=3.36) this proves that Mulligan’s SNAGs is more effective in case of mechanical neck pain than Mulligan’s NAGs. Conclusion: The study concluded that Mulligan’s SNAGs are more effective than in comparison to Mulligan’s NAGs but at some point, both techniques gave significant results. Keywords: Sustained Natural Apophyseal Glides (SNAGS), Natural Apophyseal Glides (NAGS) Wong-Baker faces pain scale (WBFPS), NDI, Neck strengthening exercises, RCT