Homophobia corresponds to a series of repulsive behaviors, actions and feelings towards homosexuals, bisexuals and, in some cases, transgenders and intersexuals and is a serious public health problem. During the manifestation of homophobia, the feelings that prevail to exemplify the definition of the term are antipathy, contempt, prejudice, aversion and irrational fear. Thus, this study aimed to analyze homophobia and gender violence against lesbians, gays, bisexuals and transgender people in Brazil. It is a descriptive, exploratory study based on an integrative review of the literature. It was conducted at the Virtual Health Library through the following online databases: Latin American and Caribbean Literature in Health Sciences, Nursing Database, Medical Literature Analysis and Retrieval System Online and Google Scholar. The sample consisted of nine articles after the application of the eligibility criteria. A semi-structured form was used as a data collection tool. According to the sample, most of the participants already researched suffered some type of homophobic violence. Psychological violence, followed by physical and sexual violence, is mainly addressed. The vulnerability of the young people is determined by the series of attitudes taken by their families when they receive disclosure of their sexual orientation, which are: expulsions, persecutions, and reprehension. Homophobia causes negative self-perception, prevents the acquisition of healthy life habits, and promotes suicidal ideas. Therefore, it is necessary to intervene through a multiprofessional team to monitor the health of these adolescents, as well as to implement strict laws against these homophobic individuals who practice illicit acts that attack the life of a human being. In education, one must pay attention to the bullying practiced by students, in view of the beginning of violence and psychological suffering that the adolescent will go through.