This paper describes designing an efficient mesh topology Network-on-Chip system by employing MPLS protocol as an on-chip communication technique. A discrete-event simulator is developed in C++ to show the applicability of MPLS in providing efficient on-chip communication for multicore processing system-on-chip designs. Experimental results are compared with two simulators: wormhole equipped with virtual channels; and MPLS-based fat tree network-on-chip systems. Outstandingly, MPLS as on-chip communication means recorded better results than the wormhole +virtual channels in terms of throughput and packet end-to-end delay (latency).