Protein codes for tetrameric and dimeric 6-phosphogluconate dehydrogenases and their signature sequence relevant to the cofactor specificity in the 6PGDH family.

Here we present the Uniprot or Genbank code for tetrameric and dimeric 6-phosphogluconate dehydrogenases collected from different organisms. Besides, we include the sequence of the \(\beta2-\alpha2\) motif regarding the cofactor specificity in the 6PGDH family. The sequence data allows generating a phylogenetic tree of the 6PGDH family. The enzymes cluster first by their oligomerization state and then by their sequence in the \(\beta2-\alpha2\) motif, as is shown in the annexed figure.

Related Organizations

University of Chile
Chile

Keywords

cofactor specificity, 6-phosphogluconate dehydrogenases, phylogenetic tree, protein evolution

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