The objective of present study was to develop self-emulsifying drug delivery system (SEDDS) of model drug Spironolactone. Self-emulsified formulations are in focus of recent research due to its advantages like it enhances the bioavailability of oral lipophilic drugs, reduced dosing frequency and the tendency to load both hydrophilic and lipophilic drugs. The self-emulsions were prepared by using different ratios of oil and surfactant/co- surfactant with water. The prepared self-emulsions were evaluated for emulsification time, preliminary stability indicating study, % transmission measurement and drug content. Drug content of all the prepared self-emulsions was ranged from 91.43% to 96.76 %. In-vitro permeation results revealed that 82.03%- 95.00% of drug permeate from the formulations in 80 mins. study period. The F6 was selected as the best optimised formulation. Hence it was concluded that poorly soluble drugs such as Spironolactone can be effectively formulated as SEDDS this may improve bioavailability followed by patient compliance. Keywords: Self emulsifying drug delivery system (SEDDS), Oil, Co-surfactant, Surfactant.