Spectra of the targets in the Orion OB1 and sigma Orionis regions observed with the VLT/ESPRESSO spectrograph in November-December 2020. These spectra are part of the PENELLOPE Large Program and are obtained close in time to the HST/ULLYSES spectra of the same targets. Here one can find the 1D flux-calibrated and telluric corrected spectra. Each object is observed simultaneously in three arms, blue, redu, redl, and the spectrum of each arm is saved in one file. The units of the spectra are: Flux [erg/s/cm2/AA]; Wavelength [AA]. Each object is observed 3 times, the spectra are thus labelled as ep1, ep2, ep3. Only CVSO90 was observed just one time. Data are public, we ask to ask to the authors of this release, who contributed to the observation preparation and data reduction, whether they want to be included in any publication using these data. The data are presented in Manara et al. (2021), currently in prep. For questions or comments please contact Carlo Manara, cmanara@eso.org