Objective: To assess endocrine confrontation between CRF victims was the objective of this exploration research. Victims and Methods: All the recruited victims did not show any dialysis or diabetes history. This crosswise exploration was carried out on a total of 50 victims being treated for structural renal abnormalities or deranged renal functions at Sir Ganga Ram Hospital, Lahore (December 2018 to November 2019). All the victims were screened for lipid profile, renal function tests, complete blood count (CPC), antiserum endocrine stages and fasting plasma glucose. Another fifty healthy controls were also included in the exploration of the same age Set. We made a statistical examination of exploration outcomes on SPSS software. HOMA-IR method was used for the calculation of endocrine confrontation. Results: Men dominated ladies in number in cases. We enrolled controls and cases having fifty in each Set. On the other hand, in controls 26% were ladies and 74% were men. Total of 34% of the cases were ladies; whereas, 66% were men. CRF victims showed higher stages of fasting endocrine and importantly higher HOMA-IR in comparison to controls (P-Value 0.001). The lipid profile showed an important difference in the stages of triglycerides in statistical examination. The Average age of controls and cases was respectively (49 ± 9) years and (50 ± 10) years. Conclusion: HOMA-IR was importantly higher between CRF victims which clearly shows an association between endocrine confrontation and CRF. Keywords: CRF, HOMA-IR, Endocrine Confrontation, and Hypertriglyceridemia.