Introduction: An old but time-tested proverb “If the eyes are a window to the soul, then the mouth is the doorway to the body” reflects the importance of oral health. Objectives: The main objective of the study is to analyse the beneficial effects of miswak versus toothpaste among local population of Pakistan. Material and methods: This cross sectional study was conducted in Jinnah Post Graduate Medical Centre, Karachi during June 2019 to January 2020. The data was collected for the comparison analysis of miswak and tooth paste for oral hygiene practice. Results: The components evaluated in all the study were used to explain the dental hygiene: recognition and practices among the studied community. Though, direct contrast of the study findings in one study to those in another has not been strived as the methods used were not exactly the same. Data collection place was done sample wise. Conclusion: It is concluded that miswak alone is more beneficial than toothbrushes and toothpaste/mouthwash. Besides removing plaque, calculus, and debris it also provides the remedy to anti-sensitize the teeth.