Pending the females arrives at the 40 yrs of age, atresia sluggish, at that time the number of follicles stayed arrives at a dangerous doorstep. When the birth period is completed in the females we observe the lessening of number of chromosomes containing partial somatic cells in the female’s reproductive organ. Prior to birth, half of the follicle puddle is misplaced. This occurs at the middling age of 51 yrs. Again atresia becomes fast at this stage again and female developed through the reproductive aging until when no eggs in the ovary of female present more. A large number of hormonal discharges occur on the basis of reaction towards follicles in every periodic cycle. We notice the less formation of B inhibin and almost no secretion of follicle stimulating hormone (FSH) when only smaller numbers of ovaries are present in the female body. A research named Research of Females across the Nation (SWAN) was organized to recognize the changes in the hormonal discharge of the females. Sometimes females face unsuitable production of follicles and sometimes normal production. These two conditions alternate simultaneously. It was observed that females of the larger ages and larger weight bearing showed less discharge of hormones. This recognition was made by examining the urine of the female every day. At the time of start of menstruation progression less production of luteinizing hormone was also observed. Less production of estradiol and more release of FSH was seen in the older females at the time stoppage of reproductive cycle. Throughout the progression we noticed the changes in every reproductive cycle, not only the ovary. Changes in the hormonal secretion of reproductive cycle indicate the perimenopause. Central anxious system of the female fails to react normally towards the secretion of various hormone so imbalance in the production of hormones results. Keywords: Menstruation transition; ovarian aging, an ovulation; FSH; Inhibin.