HEV as we all know is an infectious disease and its factors include as that of acute hepatitis. It is a RNA virus and its way of transmission is fecal or oral route. Water source that is contaminated with Hepatitis E virus can cause its widespread mainly in tropical and subtropical areas, it is an endemic. It has been reported that there were around fifty outbreaks of this disease in central Asia, South East part of Asia, whole Africa and Mexico. Hepatitis E virus should be considered as an acute hepatitis because its prevalence is high among children who go to primary school. The reason of it being highly prevalent is the lack of proper sanitation system in Sialkot city. Therefore to prevent the endemic clean water sources and proper hygiene must be ensured.