Acute pancreatitis is an inflammatory disease that changes from mild interstitial edema of the pancreas to extreme type of pancreatic necrosis and hemorrhage. In this study, frequency and in the development of infected pancreatic necrosis after acute pancreatitis were noted. A total of 105 patients [Male and Female] with age range 40-75 year were included in this study. A random sampling technique [95% confidence level] was used for a reliable statistical conclusion. Demographic history was obtained from the patient's records included in this study and their files were reviewed including an abdominal CT scan to check for pancreatic necrosis and CT-guided fine-needle aspiration cytology [FNAC] to verify infection. Prevalence of infected acute pancreatic necrosis among the patients of severe acute pancreatitis was n=34/105 i.e 32% of the total patients. The main contributing factors in developing the infective pancreatic necrosis are choledocholithiasis, gallstones, hypercalcemia, idiopathy, pancreatic or ampullary tumors, trauma, and hypothermia respectively. Keywords: Infection, severe acute pancreatitis, CT, Ranson, gall-stone, idiopathic.