Objective: Diabetes mellitus is a fundamental infection having genuine micro-vascular and macro-vascular entanglements. Micro vascular intricacies incorporate diabetic nephropathy (DN), diabetic retinopathy, and diabetic neuropathy while macro-vascular confusions incorporate stroke, cardiovascular ailments (CVDs), and fringe vascular diseases. Aim of the study was to determine the role of Neutrophil / lymphocyte ratio in diabetes 2 nephropathy Study Design: This was an Observational / cross sectional Study Place and Duration of Study: This study was conducted at the Jinnah Hospital Lahore during May 2019 to May 2020. Materials and Methods: It is an observational cross-sectional study. Totally 115 diagnosed type 2 diabetes mellitus patients were registered in this study. NLR was calculated by analyzing differential leukocyte count in complete blood picture. Albuminuria was tested by MICRAL-II TEST strips by dipstick method. Demographic data and laboratory Investigations were recorded on designed Performa. Informed written consent was taken from every patient before collecting the sample, history and examination. Permission of Ethical Committee of the Institute was considered for collection of data and get publishing in medical journal. Results: Totally 115 diabetic patients were registered. About 56 patients had DN and 59 had normal urine albumin. Mean NLR for a normal group is 1.94 ± 0.65 and in DN group is 2.83 ± 0.85 which was highly significant (P < 0.001). Estimated glomerular filtration rate (P = 0.047) and serum glutamate pyruvate transaminase (P < 0.001) were also significant. Conclusion: The results of our study show that there was a significant relation between NLR and DN. Therefore, NLR may be considered as a novel surrogate marker of DN in early stages. Key Words: Diabetic nephropathy, inflammation, microvascular, neutrophil-lymphocyte ratio, urine albumin