Following the episode of the severe extreme respiratory disease on the earth, human Covid has been described as microorganisms that cause significant evidence of respiratory lot infection. Lately, another HCoV segregated from the respiratory epithelium of unidentified pneumonia patients on the Wuhan fish market induced a major disease episode and was referred to as the extreme severe respiratory syndrome of Covid 2 (SARS-CoV-2). Our current research was conducted at PIMS, Islamabad from February 2019 to October 2019. This infection triggers severe pulmonary symptoms, leading to a disease called "Covid infection 2019" (COVID-19). The rise of SARS-CoV-2 and SARS-CoV induced boundless fear and worry and threatened the stability of the world's well-being. There are a few distinctions and contrasts in the disease transmission analysis and clinical highlights of these two infections, the diseases caused by these infections. The purpose of this work is to investigate and consider purposely between SARS-CoV and SARS-CoV-2 with respect to their infection, initiation, conclusion and treatment methods, genomic and proteomic successions and pathogenic components. Keywords: Comprehensive Evaluation, Animal-to-Human Transmitted, Human Coronaviruses.