Introduction: Cirrhosis represents a late stage of progressive hepatic fibrosis characterized by distortion of the hepatic architecture and the formation of regenerative nodules. Objectives: The main objective of the study is to analyse the thrombocytopenia and grading of esophageal varices in patients of chronic liver disease. Material and methods: This cross sectional study was conducted in Shifa International Hospital, Islamabad during June 2019 to December 2019. Patients fulfilling the inclusion and exclusion criteria were included in the study after taking informed consent. Results: From 215 patients, the minimum age was calculated as 18 years and maximum age was 60 years with mean + standard deviation 36.30 + 13.66 years. The minimum platelet count was calculated as 40000 and maximum platelet count was 180000 with mean + standard deviation 122707 + 48500.43. The minimum duration of CLD was calculated as 6 months and maximum duration of CLD was 24 months with mean + standard deviation 14.37 + 5.13 months. Conclusion: Thrombocytopenia was present in 36.3% patients while Esophageal varices was present in 27.9% patients. Significant correlation was found between presence of thrombocytopenia and presence of esophageal varices. Effect modifiers also showed significant influence.