Objective: To assess the effectiveness and protection of ferruginous ascorbate, given verbally three time daily for 90 days, to pre- premenstrual females with extreme iron insufficiency etiolated. Method: A stage-IV non scrambled particular arm exposed brand medicine test was led at Gynecology and Tocology. A recognized principled evaluation panel accepted the research procedure preceding to research commencement. By expending the lenient example extent calculator, as the percentage 43.0% of Victims with iron insufficiency etiolated with brim of fault 5.0% and 95.0% sureness stage, an projected sample extent of fifty was considered. Hemoglobin (Hb) among 6 to 8 gm/dl were registered subsequently taking transcribed conversant consensus. Scientific assessment and lab examination for opsonin protein and hemoglobin stages were led at standard and subsequently conclusion of handling. A consistent proformae for statistics gathering was established. Ferruginous ascorbate lenient aspic tablets were given, one tablet through or later the mealtime three times every day, for 90 days. All Victims were assessed 4 times through research first at the time of conscription and after 1, 2, and 3 months for scientific effectiveness and protection evaluation. Results: In this research all 50 premenstrual females finished iron cure. Exploration of healing effectiveness constraints i.e. hemoglobin, and protein echelons presented development that was analytically important. At the conclusion of cure with verbal ferruginous ascorbate, important enhancement in Hb echelons was perceived (7.577 ± 0.557 gm/dl Vs 11.022 ± 0.715, p<0.0001). Important variations were distinguished in opsonin protein level (10.056 ± 5.057 mg/ml Vs 27.138 ± 13.805, p<0.0001) after 90 days treatment. Ferruginous ascorbate showed to be innocuous in females with extreme iron insufficiency etiolated. The cured females didn’t display any main cross result, only one thoughtful cross result was conveyed (erythema leprosum). Slight self-preventive cross possessions comprising black discoloration of seat in 54.0 % cases, biliousness in 6.0%, degradation in 2.0% and diarrhea in 2.0% was detected. Conclusion: Verbal ferruginous ascorbate handling for extreme iron insufficiency etiolated is healthy accepted and extremely in effect in premenstrual females. Keywords: Hemoglobin, protein, Iron-insufficiency etiolated, Ferruginous ascorbate, Premenstrual.