Aim:“Cryptococcal meningitis” is the most vital HIV-associated opportunistic infections, in the developing world. In order to aid establish worldwide strategies and procedures for precaution and curement, it is necessary to approximate the hurdle of cryptococcal meningitis. Design: Worldwide burden of ailment estimation through published studies. Procedure: We utilized the median incidence rate of some studies in a specific area to approximate the “area-specific cryptococcal meningitis prevalence”; this was increased by the 2005 U.N Program on “HIV/AIDS” HIV population approximate for each area to approximate cryptococcal meningitis cases. To approximate mortality, we presumed a 10% 2.5 month fatality rate of case in socioeconomic area, a 45% rate in poor and normal-income area, and a 69% proportion in “sub-Saharan Africa,” on the basis of studies published in such areas and expert suggestion. Results: Documented incidence was from 0.05 to 11% annually in HIV patients. “Sub-Saharan Africa” had the highest annual burden approximate (median incidence 4.2 Central Europe, %, 620 000 cases; range of 154 000–1.2 million). Median incidence was least in Western and Oceania, which is ≤0. 2% each. Internationally, about 856 900 cases with range of, 381 700–1 644 000 of cryptococcal meningitis spreads annually, resulting in 524 700 mortality with range of, 135 000–1 224 900 by 2.5 months of infection. To Conclude: This article, the first try to approximate the worldwide burden of “cryptococcal meningitis,” finds the cases and mortality to be high, with most occurring in “sub-Saharan Africa.” More is needed to define the aim of the issue and identify the epidemiology of such infection, in order to better prevention, investigation, and treatment plans.